Article
The AA genotype of a L1C G842A polymorphism is associated with an increased risk for ovarian cancer.
Anticancer research - 1 Aug 2009
Heubner Martin, Wimberger Pauline, Kasimir-Bauer Sabine, Otterbach Friedrich, Kimmig Rainer, Siffert Winfried
Abstract excerpt
BACKGROUND: Recent studies proposed L1CAM (L1 cell adhesion molecule) expression as a negative prognostic marker in epithelial ovarian cancer (EOC). The gene L1C was screened for single nucleotide polymorphisms (SNPs) which could impact upon EOC risk or disease progression. PATIENTS AND METHODS: Overlapping DNA fragments, including the promoter region, intron 1 and all the exons of 10 healthy volunteers were...
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