Article
Genetic variation at chromosome 1p13.3 affects sortilin mRNA expression, cellular LDL-uptake and serum LDL levels which translates to the risk of coronary artery disease.
Atherosclerosis - 1 Jan 2010
Linsel-Nitschke Patrick, Heeren Jörg, Aherrahrou Zouhair, Bruse Petra, Gieger Christian, Illig Thomas, Prokisch Holger, Heim Katharina, Doering Angela, Peters Annette, Meitinger Thomas, Wichmann H-Erich, Hinney Anke, Reinehr Thomas, Roth Christian, Ortlepp Jan R, Soufi Mouhidien, Sattler Alexander M, Schaefer Jürgen, Stark Klaus, Hengstenberg Christian, Schaefer Arne, Schreiber Stefan, Kronenberg Florian, Samani Nilesh J, Schunkert Heribert, Erdmann Jeanette
Abstract excerpt
BACKGROUND: A single nucleotide polymorphism (SNP) rs599839 located at chromosome 1p13.3 has previously been associated with risk of coronary artery disease (CAD) and with serum levels of low-density lipoprotein cholesterol (LDL-C). A functional link explaining the association of SNP rs599839 with LDL-C levels and CAD risk has not yet been elucidated. METHODS: We analyzed the association of rs599839 with LDL-C in...
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