Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Sortilin as a regulator of lipoprotein metabolism.

Current atherosclerosis reports - 1 Jun 2012

Strong Alanna, Rader Daniel J

Abstract excerpt

Elevated low-density lipoprotein cholesterol (LDL-C) is associated with increased risk of atherosclerotic cardiovascular disease (ASCVD) and myocardial infarction (MI). Much of the insight into LDL metabolism has been gained through the study of Mendelian disorders of lipid metabolism. Genome-wide associations studies (GWAS) are now being used to identify novel genes and loci that contribute to variations in...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adaptor Proteins, Vesicular Transport
Share to Atherosclerosis
Share to Gene Expression Regulation

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to SORT1 gene

Share to Genetic Predisposition to Disease

Share to Genome-Wide Association Study

Share to Lipid Metabolism

Share to Lipids

Source

Open in PubMed Open full text

Identifiers

PMID: 22538429
DOI: 10.1007/s11883-012-0248-x
PMCID: PMC7089359

Genes

SORT1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Sortilin as a regulator of lipoprotein metabolism.PMID 22538429Read ↗

Sortilin: an unusual suspect in cholesterol metabolism: from GWAS identification to in vivo biochemical analyses, sortilin has been identified as a novel mediator of human lipoprotein metabolism.Semantic proximity Read ↗

New insight into sortilin in controlling lipid metabolism and the risk of atherogenesisSemantic proximity Read ↗

Sortilin: the mechanistic link between genes, cholesterol, and coronary artery disease.Semantic proximity Read ↗

Sortilin and lipoprotein metabolism: making sense out of complexity.Semantic proximity Read ↗

Sort1, encoded by the cardiovascular risk locus 1p13.3, is a regulator of hepatic lipoprotein export.Semantic proximity Read ↗

Sortilin, Encoded by the Cardiovascular Risk Gene SORT1, and Its Suggested Functions in Cardiovascular DiseaseSemantic proximity Read ↗

Genome-wide association studies identify new targets in cardiovascular disease.Semantic proximity Read ↗

Autophagy Is Required for Sortilin-Mediated Degradation of Apolipoprotein B100Semantic proximity Read ↗

The effect of SORT1 rs: 599839 polymorphism on lipid profiles in Turkish population Runing Title: Relationship of rs599839 and lipid profilesSemantic proximity Read ↗

Metabolomics reveals the sex-specific effects of the SORT1 low-density lipoprotein cholesterol locus in healthy young adults.Semantic proximity Read ↗

Genetic variation at chromosome 1p13.3 affects sortilin mRNA expression, cellular LDL-uptake and serum LDL levels which translates to the risk of coronary artery disease.Semantic proximity Read ↗

Effect of the SORT1 low-density lipoprotein cholesterol locus is sex-specific in a fit, Canadian young-adult population.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.