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Article

Sortilin: the mechanistic link between genes, cholesterol, and coronary artery disease.

Cardiology in review - 1 Jan 2000

Thaker Adarsh M, Frishman William H

Abstract excerpt

Hyperlipidemia is an important risk factor for cardiovascular disease globally, but there is still much mystery surrounding the topic of lipid regulation. Many studies have attempted to assess the underlying genetic basis of low-density lipoprotein (LDL) metabolism. Recently, multiple genome-wide association studies identified genes that strongly associate with plasma lipid concentration and cardiovascular...

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Topics

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Share to Adaptor Proteins, Vesicular Transport
Share to Cholesterol, LDL
Share to Coronary Artery Disease

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Polymorphism, Single Nucleotide

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Source

Identifiers

PMID: 24500115
DOI: 10.1097/CRD.0000000000000008

Genes

SORT1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

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Sortilin: the mechanistic link between genes, cholesterol, and coronary artery disease.PMID 24500115Read ↗

Sortilin as a regulator of lipoprotein metabolism.Semantic proximity Read ↗

Sortilin: an unusual suspect in cholesterol metabolism: from GWAS identification to in vivo biochemical analyses, sortilin has been identified as a novel mediator of human lipoprotein metabolism.Semantic proximity Read ↗

Sortilin and lipoprotein metabolism: making sense out of complexity.Semantic proximity Read ↗

New insight into sortilin in controlling lipid metabolism and the risk of atherogenesisSemantic proximity Read ↗

Sortilin, Encoded by the Cardiovascular Risk Gene SORT1, and Its Suggested Functions in Cardiovascular DiseaseSemantic proximity Read ↗

Sort1, encoded by the cardiovascular risk locus 1p13.3, is a regulator of hepatic lipoprotein export.Semantic proximity Read ↗

Genome-wide association studies identify new targets in cardiovascular disease.Semantic proximity Read ↗

Genetic variation at chromosome 1p13.3 affects sortilin mRNA expression, cellular LDL-uptake and serum LDL levels which translates to the risk of coronary artery disease.Semantic proximity Read ↗

Autophagy Is Required for Sortilin-Mediated Degradation of Apolipoprotein B100Semantic proximity Read ↗

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