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Article

Sort1, encoded by the cardiovascular risk locus 1p13.3, is a regulator of hepatic lipoprotein export.

Cell metabolism - 8 Sept 2010

Kjolby Mads, Andersen Olav M, Breiderhoff Tilman, Fjorback Anja W, Pedersen Karen Marie, Madsen Peder, Jansen Pernille, Heeren Joerg, Willnow Thomas E, Nykjaer Anders

Abstract excerpt

Recent genome-wide association studies (GWAS) have revealed strong association of hypercholesterolemia and myocardial infarction with SNPs on human chromosome 1p13.3. This locus covers three genes: SORT1, CELSR2, and PSRC1. We demonstrate that sortilin, encoded by SORT1, is an intracellular sorting receptor for apolipoprotein (apo) B100. It interacts with apoB100 in the Golgi and facilitates the formation and...

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Share to Adaptor Proteins, Vesicular Transport
Share to Apolipoprotein B-100

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Chromosomes, Human, Pair 1

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Share to Lipoproteins, LDL

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Source

Identifiers

PMID: 20816088
DOI: 10.1016/j.cmet.2010.08.006

Genes

SORT1
CELSR2
PSRC1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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