Article
Presence of lysine at aa 335 of the hemagglutinin-neuraminidase protein of mumps virus vaccine strain Urabe AM9 is not a requirement for neurovirulence.
Vaccine - 25 Sept 2009
Sauder Christian J, Zhang Cheryl X, Link Malen A, Duprex W Paul, Carbone Kathryn M, Rubin Steven A
Abstract excerpt
The recent global resurgence of mumps has drawn attention to the continued need for robust mumps immunization programs. Unfortunately, some vaccines derived from inadequately attenuated vaccine strains of mumps virus have caused meningitis in vaccinees, leading to withdrawal of certain vaccine st...
Topics
- Amino Acid Substitution
- Animals
- Chlorocebus aethiops
- DNA, Complementary
- HN Protein
- Humans
- Lysine
- Mumps Vaccine
- Mumps virus
- Mutation
- RNA, Viral
- Rats