Article
Structure-function analysis of two variants of mumps virus hemagglutinin-neuraminidase protein.
The Brazilian journal of infectious diseases : an official publication of the Brazilian Society of Infectious Diseases - 1 Feb 2009
Santos-López Gerardo, Scior Thomas, Borraz-Argüello María del Tránsito, Vallejo-Ruiz Verónica, Herrera-Camacho Irma, Tapia-Ramírez José, Reyes-Leyva Julio
Abstract excerpt
A point mutation from guanine (G) to adenine (A) at nucleotide position 1081 in the hemagglutinin-neuraminidase (HN) gene has been associated with neurovirulence of Urabe AM9 mumps virus vaccine. This mutation corresponds to a glutamic acid (E) to lysine (K) change at position 335 in the HN glyco...
Topics
- Amino Acid Substitution
- Animals
- Cell Line, Tumor
- Chlorocebus aethiops
- Genetic Variation
- HN Protein
- Humans
- Mumps Vaccine
- Mumps virus
- Point Mutation
- Structure-Activity Relationship
- Vero Cells