Article
Genetic heterogeneity of L-Zagreb mumps virus vaccine strain.
Virology journal - 10 Jul 2008
Kosutic-Gulija Tanja, Forcic Dubravko, Santak Maja, Ramljak Ana, Mateljak-Lukacevic Sanja, Mazuran Renata
Abstract excerpt
BACKGROUND: The most often used mumps vaccine strains Jeryl Lynn (JL), RIT4385, Urabe-AM9, L-Zagreb and L-3 differ in immunogenicity and reactogenicity. Previous analyses showed that JL, Urabe-AM9 and L-3 are genetically heterogeneous. RESULTS: We identified the heterogeneity of L-Zagreb throughout the entire genome. Two major variants were defined: variant A being identical to the consensus sequence of viral...
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