Article
Functional consequences of attenuating mutations in the haemagglutinin neuraminidase, fusion and polymerase proteins of a wild-type mumps virus strain.
The Journal of general virology - 1 Sept 2007
Malik Tahir, Wolbert Candie, Mauldin Jeremy, Sauder Christian, Carbone Kathryn M, Rubin Steven A
Abstract excerpt
Wild-type mumps viruses (MuVs) are highly neurotropic and, prior to widespread vaccination programmes, were a major cause of viral meningitis and encephalitis in most developed countries. At present, there are no markers for virus attenuation, apart from the failure of a passaged isolate to produ...
Topics
- Animals
- Cell Line
- Chick Embryo
- DNA Primers
- DNA-Directed DNA Polymerase
- DNA-Directed RNA Polymerases
- Gene Fusion
- HN Protein
- HeLa Cells
- Humans
- Kinetics
- Mumps virus
- Mutation
- Neuraminidase
- Polymerase Chain Reaction
- RNA, Viral
- Reverse Transcriptase Polymerase Chain Reaction
- Threonine