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Article

Genetic polymorphisms of EPHX1, Gsk3beta, TNFSF8 and myeloma cell DKK-1 expression linked to bone disease in myeloma.

Leukemia - 1 Oct 2009

Durie B G M, Van Ness B, Ramos C, Stephens O, Haznadar M, Hoering A, Haessler J, Katz M S, Mundy G R, Kyle R A, Morgan G J, Crowley J, Barlogie B, Shaughnessy J

Abstract excerpt

Bone disease in myeloma occurs as a result of complex interactions between myeloma cells and the bone marrow microenvironment. A custom-built DNA single nucleotide polymorphism (SNP) chip containing 3404 SNPs was used to test genomic DNA from myeloma patients classified by the extent of bone disease. Correlations identified with a Total Therapy 2 (TT2) (Arkansas) data set were validated with Eastern Cooperative...

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Source

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Identifiers

PMID: 19657367
DOI: 10.1038/leu.2009.129
PMCID: PMC3684359

Genes

EPHX1
TNFSF8

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