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Article

ASPP2 is a haploinsufficient tumor suppressor that cooperates with p53 to suppress tumor growth.

Genes & development - 15 May 2006

Vives Virginie, Su Jian, Zhong Shan, Ratnayaka Indrika, Slee Elizabeth, Goldin Robert, Lu Xin

Abstract excerpt

ASPP2 stimulates the apoptotic function of the p53 family in vivo. We show here that ASPP2-/- pups died before weaning. This postnatal lethality was significantly enhanced in p53+/- background and both deletions are synthetic lethal. ASPP2+/- mice developed spontaneous tumors. The tumor onset was accelerated by gamma-irradiation or in p53+/- background. Tumors derived from ASPP2+/- mice retained wild-type ASPP2...

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Identifiers

PMID: 16702401
DOI: 10.1101/gad.374006
PMCID: PMC1472901

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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