Article

Identification of Proteinase Activated Receptor (PAR) cleaving enzymes in human osteoarthritis knee joint synovial fluids

2020-10-22

Abstract excerpt

<h4>ABSTRACT</h4> <h4>Objective</h4> Osteoarthritis (OA) is the most prevalent joint disorder with incidence increasing worldwide. Mechanistic insights into OA pathophysiology are still evolving and there are currently no disease-modifying OA drugs available. It is well established that an increase in proteolytic enzyme activity is linked to progressive degradation of the cartilage in OA. Proteolytic enzymes can...

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Literature Corpus work: 95f1f172-fdd0-5f1d-995e-a4310ff22dd1
DOI: 10.1101/2020.10.21.336693

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