Article
Protein kinase C theta co-operates with calcineurin in the activation of slow muscle genes in cultured myogenic cells.
Journal of cellular physiology - 1 May 2006
D'Andrea M, Pisaniello A, Serra C, Senni M I, Castaldi L, Molinaro M, Bouché M
Abstract excerpt
Adult skeletal muscle fibers can be divided into fast and slow twitch subtypes on the basis of specific contractile and metabolic properties, and on distinctive patterns of muscle gene expression. The calcium, calmodulin-dependent protein phosphatase, calcineurin, stimulates slow fiber-specific genes (myoglobin (Mb), troponin I slow) in cultured skeletal muscle cells, as well as in transgenic mice, through the...
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