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Article

IGF-I activates the mouse type IIb myosin heavy chain gene.

American journal of physiology. Cell physiology - 1 Oct 2009

Shanely R Andrew, Zwetsloot Kevin A, Childs Thomas E, Lees Simon J, Tsika Richard W, Booth Frank W

Abstract excerpt

IGF-I increases skeletal muscle mass, but whether IGF-I increases type IIb myosin heavy chain (MyHC) transcriptional activity is not known. C2C12 myotubes were cultured with or without IGF-I to determine whether IGF-I increases type IIb MyHC promoter activity, and if so, what region of the promoter might IGF-I signaling regulate. At differentiation days 3 and 4, IGF-I increased type IIb MyHC mRNA and mouse 3.0-kb...

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Source

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Identifiers

PMID: 19657059
DOI: 10.1152/ajpcell.00169.2009
PMCID: PMC2770749

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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