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Article

Imprinting regulates mammalian snoRNA-encoding chromatin decondensation and neuronal nucleolar size

5 Aug 2009

Abstract excerpt

Imprinting, non-coding RNA and chromatin organization are modes of epigenetic regulation that modulate gene expression and are necessary for mammalian neurodevelopment. The only two known mammalian clusters of genes encoding small nucleolar RNAs (snoRNAs), SNRPN through UBE3A(15q11-q13/7qC) and GTL2(14q32.2/12qF1), are neuronally expressed, localized to imprinted loci and involved in at least five...

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PMID: 19656775
DOI: 10.1093/hmg/ddp373

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