Article
Structure and function correlations at the imprinted mouse Snrpn locus.
Mammalian genome : official journal of the International Mammalian Genome Society - 1 Oct 1998
Gabriel J M, Gray T A, Stubbs L, Saitoh S, Ohta T, Nicholls R D
Abstract excerpt
The human SNRPN gene maps within Chromosome (Chr) 15q11-q13, the region responsible for Prader-Willi syndrome (PWS) and Angelman syndrome (AS). As one of several 15q11-q13 transcripts expressed from the paternal allele-only, SNRPN is a candidate gene to explain at least some of the PWS phenotype in human and in genetic mouse models. The promoter and first exon of the SNRPN gene also correspond to an imprinting...
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