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Article

Molecular characterization of novel progranulin (GRN) mutations in frontotemporal dementia.

Human mutation - 1 Apr 2008

Mukherjee Odity, Wang Jun, Gitcho Michael, Chakraverty Sumi, Taylor-Reinwald Lisa, Shears Shantia, Kauwe John S K, Norton Joanne, Levitch Denise, Bigio Eileen H, Hatanpaa Kimmo J, White Charles L, Morris John C, Cairns Nigel J, Goate Alison

Abstract excerpt

Frontotemporal dementia (FTD) is a clinical term encompassing dementia characterized by the presence of two major phenotypes: 1) behavioral and personality disorder, and 2) language disorder, which includes primary progressive aphasia and semantic dementia. Recently, the gene for familial frontotemporal lobar degeneration (FTLD) with ubiquitin-positive, tau-negative inclusions (FTLD-U) linked to chromosome 17 was...

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Identifiers

PMID: 18183624
DOI: 10.1002/humu.20681
PMCID: PMC2756561

Genes

GRN

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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