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Article

Functional screening of FGFR4-driven tumorigenesis identifies PI3K/mTOR inhibition as a therapeutic strategy in rhabdomyosarcoma.

Oncogene - 1 May 2018

McKinnon Timothy, Venier Rosemarie, Yohe Marielle, Sindiri Sivasish, Gryder Berkley E, Shern Jack F, Kabaroff Leah, Dickson Brendan, Schleicher Krista, Chouinard-Pelletier Guillaume, Menezes Serena, Gupta Abha, Zhang Xiaohu, Guha Rajarashi, Ferrer Marc, Thomas Craig J, Wei Yuhong, Davani Dariush, Guidos Cynthia J, Khan Javed, Gladdy Rebecca A

Abstract excerpt

Rhabdomyosarcoma (RMS) is the most common pediatric soft tissue sarcoma and outcomes have stagnated, highlighting a need for novel therapies. Genomic analysis of RMS has revealed that alterations in the receptor tyrosine kinase (RTK)/RAS/PI3K axis are common and that FGFR4 is frequently mutated or overexpressed. Although FGFR4 is a potentially druggable receptor tyrosine kinase, its functions in RMS are...

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Identifiers

PMID: 29487419
DOI: 10.1038/s41388-017-0122-y
PMCID: PMC8054765

Genes

FGFR4

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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