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Article

Emerging concepts for PI3K/mTOR inhibition as a potential treatment for osteosarcoma

2016-07-06

Abstract excerpt

Patients with metastatic and recurrent osteosarcoma fare poorly, and new therapeutic strategies are needed to improve survival. Several recent complementary genomic and pathway analyses of both murine and human osteosarcoma have revealed common aberrations of the phosphoinositide 3-kinase (PI3K)/mammalian target of rapamycin (mTOR) pathway in osteosarcoma. Preclinical data demonstrate that inhibition of PI3K and m...

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Literature Corpus work
58da60bb-858a-53a9-a3c9-390ff7b6a007
DOI
10.12688/f1000research.8228.1
Open publication

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