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Article

Identification of novel cell wall destabilizing antifungal compounds using a conditional Aspergillus nidulans protein kinase C mutant.

The Journal of antimicrobial chemotherapy - 1 Oct 2009

Mircus Gabriel, Hagag Shelly, Levdansky Emma, Sharon Haim, Shadkchan Yona, Shalit Itamar, Osherov Nir

Abstract excerpt

OBJECTIVES: Despite the need for novel drugs to combat fungal infections, antifungal drug discovery is currently limited by both the availability of suitable drug targets and assays to screen corresponding targets. The aim of this study was to screen a library of small chemical compounds to identify cell wall inhibitors using a conditional protein kinase C (PKC)-expressing strain of Aspergillus nidulans. This...

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Source

Identifiers

PMID: 19648579
DOI: 10.1093/jac/dkp270

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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