Article
Origin and pathogenesis of nodular lymphocyte-predominant Hodgkin lymphoma as revealed by global gene expression analysis.
The Journal of experimental medicine - 29 Sept 2008
Brune Verena, Tiacci Enrico, Pfeil Ines, Döring Claudia, Eckerle Susan, van Noesel Carel J M, Klapper Wolfram, Falini Brunangelo, von Heydebreck Anja, Metzler Dirk, Bräuninger Andreas, Hansmann Martin-Leo, Küppers Ralf
Abstract excerpt
The pathogenesis of nodular lymphocyte-predominant Hodgkin lymphoma (NLPHL) and its relationship to other lymphomas are largely unknown. This is partly because of the technical challenge of analyzing its rare neoplastic lymphocytic and histiocytic (L&H) cells, which are dispersed in an abundant nonneoplastic cellular microenvironment. We performed a genome-wide expression study of microdissected L&H lymphoma...
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