Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Genotypic analyses of Hodgkin's disease.

Molecular biology & medicine - 1 Dec 1990

Bernard D J, Bignon Y J, Fonck Y, Ramos F, Chassagne J, Chollet P, Plagne R

Abstract excerpt

In spite of the use of molecular biology, the cellular lineage and clonality of Reed-Sternberg cells, the abnormal cells of Hodgkin's disease, remain an enigma. We studied the pattern of rearrangements at immunoglobulin and T-cell receptor loci in 23 patients suffering from Hodgkin's disease. Two out of 23 patients exhibited immunoglobulin gene rearrangements. No rearrangements of the T-cell receptor beta-chain...

Topics

Antigens, CD
Blotting, Southern
DNA
DNA Probes
Gene Frequency
Gene Rearrangement, beta-Chain T-Cell Antigen Receptor
Genotype
Germ Cells
Hodgkin Disease
Humans
Immunoglobulin Heavy Chains

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Immunohistochemistry

Lymph Nodes

Phenotype

Receptors, Antigen, T-Cell

Source

Identifiers

PMID: 1963918

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1963918-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

0

discussions

0

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Genotypic analyses of Hodgkin's disease.PMID 1963918Read ↗

Immunogenotyping in Hodgkin's disease.Semantic proximity Read ↗

Analysis of T-cell receptor and immunoglobulin gene rearrangements in the diagnosis of Hodgkin's and non-Hodgkin's lymphoma.Semantic proximity Read ↗

Molecular analysis of Hodgkin's disease with abundant Reed-Sternberg cells.Semantic proximity Read ↗

Is the Hodgkin cell a T- or B-lymphocyte? Recent evidence from geno- and immunophenotypic analysis and in-vitro cell lines.Semantic proximity Read ↗

Phenotypic and genotypic characterization of Hodgkin's disease.Semantic proximity Read ↗

Recent results on the biology of Hodgkin and Reed-Sternberg cells. I. Biopsy material.Semantic proximity Read ↗

Gene rearrangement and comparative genomic hybridization studies of classic Hodgkin lymphoma expressing T-cell antigens.Semantic proximity Read ↗

T cell receptor and immunoglobulin gene rearrangement analysis as a laboratory aid in the diagnosis of human malignant lymphoproliferative diseases.Semantic proximity Read ↗

Genotype study of non-Hodgkin's lymphoma.Semantic proximity Read ↗

The nature of Reed-Sternberg cells: phenotype, genotype, and other properties.Semantic proximity Read ↗

Immunophenotypic analysis of non-Hodgkin's lymphomas.Semantic proximity Read ↗

Molecular immunoglobulin/T-cell receptor clonality diagnosis by gene scan in lymphoproliferative disorders.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.