Article
Age-related changes of the 3'APOB-VNTR genotype pool in ageing cohorts.
Annals of human genetics - 1 Mar 1998
De Benedictis G, Carotenuto L, Carrieri G, De Luca M, Falcone E, Rose G, Yashin A I, Bonafè M, Franceschi C
Abstract excerpt
The analysis of seven different age cohorts (697 individuals from 10 to 109 years old) revealed age-related changes in the 3'APOB-VNTR genotype pool. By recoding the 3'APOB-VNTR alleles into three size-classes (small, S, 26-34 repeats; medium, M, 35-39 repeats; large, L, 41-55 repeats), an age-related convex trajectory of the frequency of SS homozygotes was found. The frequency of SS in the genotype pool...
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