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Article

Impact of DNA damage repair defects on response to radium-223 and overall survival in metastatic castration-resistant prostate cancer.

European journal of cancer (Oxford, England : 1990) - 1 Sept 2020

van der Doelen Maarten J, Isaacsson Velho Pedro, Slootbeek Peter H J, Pamidimarri Naga Samhita, Bormann Maren, van Helvert Sjoerd, Kroeze Leonie I, van Oort Inge M, Gerritsen Winald R, Antonarakis Emmanuel S, Mehra Niven

Abstract excerpt

PURPOSE: Radium-223 is a targeted alpha radiation therapy for metastatic castration-resistant prostate cancer. DNA damage repair (DDR) defective prostate cancers, specifically genetic aberrations leading to homologous recombination deficiency (HRD), accumulate irreparable DNA damage following genotoxic treatment. This retrospective study assessed DDR mutation status in patients treated with radium-223,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to DNA Repair Enzymes

Share to Gene Expression Regulation, Neoplastic

Share to High-Throughput Nucleotide Sequencing

Share to Neoplasm Metastasis

Share to Prostatic Neoplasms, Castration-Resistant

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Source

Identifiers

PMID: 32634759
DOI: 10.1016/j.ejca.2020.05.001

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