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Thyroid Hormone Responsive Genes in Cultured Human Fibroblasts

1 Feb 2005

Abstract excerpt

Human skin fibroblasts are readily accessible cells for propagation in culture without transformation that can serve for direct pathophysiology studies in subjects with inherited diseases. We thus examined by quantitative fluorescent cDNA microarray analysis the effect of thyroid hormone (TH) on the expression of more than 15,000 genes in fibroblasts of two normal individuals. Fibroblasts from two subjects with...

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PMID: 15507505
DOI: 10.1210/jc.2004-1768

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