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Article

Mutational spectrum at GATA1 provides insights into mutagenesis and leukemogenesis in Down syndrome.

Blood - 24 Sept 2009

Cabelof Diane C, Patel Hiral V, Chen Qing, van Remmen Holly, Matherly Larry H, Ge Yubin, Taub Jeffrey W

Abstract excerpt

Down syndrome (DS) children have a unique genetic susceptibility to develop leukemia, in particular, acute megakaryocytic leukemia (AMkL) associated with somatic GATA1 mutations. The study of this genetic susceptibility with the use of DS as a model of leukemogenesis has broad applicability to the understanding of leukemia in children overall. On the basis of the role of GATA1 mutations in DS AMkL, we analyzed...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Share to Leukemia, Megakaryoblastic, Acute

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Source

Open in PubMed Open full text

Identifiers

PMID: 19633202
DOI: 10.1182/blood-2008-11-190330
PMCID: PMC2756130

Genes

GATA1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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