Mutants of Escherichia coli K-12 exhibiting reduced killing by both quinolone and beta-lactam antimicrobial agents.

doi:10.1128/AAC.34.10.1938

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Article

Mutants of Escherichia coli K-12 exhibiting reduced killing by both quinolone and beta-lactam antimicrobial agents.

Antimicrobial agents and chemotherapy - 1 Oct 1990

Wolfson J S, Hooper D C, McHugh G L, Bozza M A, Swartz M N

Abstract excerpt

Norfloxacin, ofloxacin, and other new quinolones, which are antagonists of the enzyme DNA gyrase, rapidly kill bacteria by largely unknown mechanisms. Earlier, we isolated, after mutagenesis, Escherichia coli DS1, which exhibited reduced killing by quinolones. We evaluated the killing of DS1 and...

Topics

Anti-Bacterial Agents
Conjugation, Genetic
Escherichia coli
Genes, Bacterial
Microbial Sensitivity Tests
Mutation
Quinolones
beta-Lactams

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