Article
Loss of phenotypic inheritance associated with ydcI mutation leads to increased frequency of small, slow persisters in Escherichia coli.
Proceedings of the National Academy of Sciences of the United States of America - 25 Feb 2020
Hingley-Wilson Suzanne M, Ma Nan, Hu Yin, Casey Rosalyn, Bramming Anders, Curry Richard J, Tang Hongying Lilian, Wu Huihai, Butler Rachel E, Jacobs William R, Rocco Andrea, McFadden Johnjoe
Abstract excerpt
Whenever a genetically homogenous population of bacterial cells is exposed to antibiotics, a tiny fraction of cells survives the treatment, the phenomenon known as bacterial persistence [G.L. Hobby et al., Exp. Biol. Med. 50, 281-285 (1942); J. Bigger, The Lancet 244, 497-500 (1944)]. Despite its biomedical relevance, the origin of the phenomenon is still unknown, and as a rare, phenotypically resistant...
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