Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Systematic study of the genetic response of a variable virus to the introduction of deleterious mutations in a functional capsid region.

Journal of virology - 1 Oct 2009

Luna Eva, Rodríguez-Huete Alicia, Rincón Verónica, Mateo Roberto, Mateu Mauricio G

Abstract excerpt

We have targeted the intersubunit interfaces in the capsid of foot-and-mouth disease virus to investigate the genetic response of a variable virus when individual deleterious mutations are systematically introduced along a functionally defined region of its genome. We had previously found that the individual truncation (by mutation to alanine) of 28 of the 42 amino acid side chains per protomer involved in...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Alanine
Share to Capsid
Share to Cricetinae

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Molecular Conformation

Share to Mutagenesis, Site-Directed

Share to RNA, Viral

Share to RNA Viruses

Share to Virus Assembly

Source

Open in PubMed Open full text

Identifiers

PMID: 19625409
DOI: 10.1128/JVI.00903-09
PMCID: PMC2748030

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Systematic study of the genetic response of a variable virus to the introduction of deleterious mutations in a functional capsid region.PMID 19625409Read ↗

Complete alanine scanning of intersubunit interfaces in a foot-and-mouth disease virus capsid reveals critical contributions of many side chains to particle stability and viral function.Semantic proximity Read ↗

Influence of the mutant spectrum in viral evolution: focused selection of antigenic variants in a reconstructed viral quasispecies.Semantic proximity Read ↗

Deterministic, compensatory mutational events in the capsid of foot-and-mouth disease virus in response to the introduction of mutations found in viruses from persistent infections.Semantic proximity Read ↗

Future prospects for the treatment of rapidly evolving viral pathogens: insights from evolutionary biology.Semantic proximity Read ↗

Globally defining the effects of mutations in a picornavirus capsid.Semantic proximity Read ↗

Different mechanisms for human rhinovirus survival in the presence of deleterious amino acid substitutions at virion protein-protein or RNA-protein interfaces.Semantic proximity Read ↗

Extreme genetic fragility of the HIV-1 capsid.Semantic proximity Read ↗

Different functional sensitivity to mutation at intersubunit interfaces involved in consecutive stages of foot-and-mouth disease virus assembly.Semantic proximity Read ↗

Genetic lesions associated with Muller's ratchet in an RNA virus.Semantic proximity Read ↗

Codon usage determines the mutational robustness, evolutionary capacity, and virulence of an RNA virus.Semantic proximity Read ↗

Targeted Modification of the Foot-And-Mouth Disease Virus Genome for Quick Cell Culture AdaptationSemantic proximity Read ↗

Helices alpha2 and alpha3 of West Nile virus capsid protein are dispensable for assembly of infectious virions.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.