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Article

Coding sequence targeting by MicC RNA reveals bacterial mRNA silencing downstream of translational initiation.

Nature structural & molecular biology - 1 Aug 2009

Pfeiffer Verena, Papenfort Kai, Lucchini Sacha, Hinton Jay C D, Vogel Jörg

Abstract excerpt

Bacterial small noncoding RNAs (sRNAs) generally recognize target mRNAs in the 5' region to prevent 30S ribosomes from initiating translation. It was thought that the mRNA coding sequence (CDS) was refractory to sRNA-mediated repression, because elongating 70S ribosomes have an efficient RNA helicase activity that prevents stable target pairing. We report that the Hfq-associated MicC sRNA silences Salmonella...

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Share to Endoribonucleases
Share to Peptide Chain Initiation, Translational

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 19620966
DOI: 10.1038/nsmb.1631

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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