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Article

Regulation of the small regulatory RNA MicA by ribonuclease III: a target-dependent pathway.

Nucleic acids research - 1 Apr 2011

Viegas Sandra C, Silva Inês J, Saramago Margarida, Domingues Susana, Arraiano Cecília M

Abstract excerpt

MicA is a trans-encoded small non-coding RNA, which downregulates porin-expression in stationary-phase. In this work, we focus on the role of endoribonucleases III and E on Salmonella typhimurium sRNA MicA regulation. RNase III is shown to regulate MicA in a target-coupled way, while RNase E is responsible for the control of free MicA levels in the cell. We purified both Salmonella enzymes and demonstrated that...

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Identifiers

PMID: 21138960
DOI: 10.1093/nar/gkq1239
PMCID: PMC3074148

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Source receipt: pubmed, retrieved 7 Sept 2026.

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