Article
Recognition of heptameric seed sequence underlies multi-target regulation by RybB small RNA in Salmonella enterica.
Molecular microbiology - 1 Oct 2010
Balbontín Roberto, Fiorini Francesca, Figueroa-Bossi Nara, Casadesús Josep, Bossi Lionello
Abstract excerpt
Prokaryotic regulatory small RNAs act by a conserved mechanism and yet display a stunning structural variability. In the present study, we used mutational analysis to dissect the functional anatomy of RybB, a σ(E)-dependent sRNA that regulates the synthesis of major porins in Escherichia coli and Salmonella. Mutations in the chromosomal rybB locus that altered the expression of an ompC-lac fusion were identified....
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