Article
The early bactericidal activity of isoniazid related to its dose size in pulmonary tuberculosis.
American journal of respiratory and critical care medicine - 1 Sept 1997
Donald P R, Sirgel F A, Botha F J, Seifart H I, Parkin D P, Vandenplas M L, Van de Wal B W, Maritz J S, Mitchison D A
Abstract excerpt
Collections of sputum from 105 patients with newly diagnosed pulmonary tuberculosis were made before and at 1 and 2 d after the start of chemotherapy with isoniazid (INH) alone given to groups of patients in doses of 600 mg, 300 mg, 150 mg, 75 mg, 37.5 mg, 18.75 mg, and 9 mg daily, as well as from an untreated group. Counts of colony forming units (cfu) of Mycobacterium tuberculosis in the collections were set up...
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