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Article

Role of SARA (SMAD anchor for receptor activation) in maintenance of epithelial cell phenotype.

The Journal of biological chemistry - 11 Sept 2009

Runyan Constance E, Hayashida Tomoko, Hubchak Susan, Curley Jessica F, Schnaper H William

Abstract excerpt

By inducing epithelial-to-mesenchymal transition (EMT), transforming growth factor-beta (TGF-beta) promotes cancer progression and fibrosis. Here we show that expression of the TGF-beta receptor-associated protein, SARA (Smad anchor for receptor activation), decreases within 72 h of exposure to TGF-beta and that this decline is both required and sufficient for the induction of several markers of EMT. It has been...

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Identifiers

PMID: 19620243
DOI: 10.1074/jbc.M109.032847
PMCID: PMC2757221

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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