Article
Study on the association of UGT1A9 gene c.98T>C polymorphism and mycophenolic acid plasma levels in renal transplant patients.
Genetics and molecular research : GMR - 31 May 2017
Ruschel L R, Schmitt V M, Silva A B, Oliveira C S A, Flach K, d'Avila D O, Thiesen F V
Abstract excerpt
Mycophenolate mofetil (MMF) is a prodrug active only after its hydrolysis to mycophenolic acid (MPA). The UGT1A9 enzyme is of special interest since it is the main enzyme involved in the glucuronidation of MPA. Single nucleotide polymorphisms (SNPs) in the UGT1A9 gene may be responsible for individual differences in the pharmacokinetics of MMF. Expression levels and the activity of UGT1A9 may depend on the...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.