Article
Inactivating germ-line and somatic mutations in polypeptide N-acetylgalactosaminyltransferase 12 in human colon cancers.
Proceedings of the National Academy of Sciences of the United States of America - 4 Aug 2009
Guda Kishore, Moinova Helen, He Jian, Jamison Oliver, Ravi Lakshmeswari, Natale Leanna, Lutterbaugh James, Lawrence Earl, Lewis Susan, Willson James K V, Lowe John B, Wiesner Georgia L, Parmigiani Giovanni, Barnholtz-Sloan Jill, Dawson Dawn W, Velculescu Victor E, Kinzler Kenneth W, Papadopoulos Nikolas, Vogelstein Bert, Willis Joseph, Gerken Thomas A, Markowitz Sanford D
Abstract excerpt
Aberrant glycosylation is a pathological alteration that is widespread in colon cancer, and usually accompanies the onset and progression of the disease. To date, the molecular mechanisms underlying aberrant glycosylation remain largely unknown. In this study, we identify somatic and germ-line mu...
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