Article
Mutation of GDP-mannose-4,6-dehydratase in colorectal cancer metastasis.
PloS one - 1 Jan 2013
Nakayama Kotarosumitomo, Moriwaki Kenta, Imai Taku, Shinzaki Shinichiro, Kamada Yoshihiro, Murata Kohei, Miyoshi Eiji
Abstract excerpt
Fucosylation is a crucial oligosaccharide modification in cancer. The known function of fucosylation in cancer is to mediate metastasis through selectin ligand-dependent processes. Previously, we found complete loss of fucosylation in the colon cancer cell line HCT116 due to a mutation in the GDP-fucose synthetic enzyme, GDP-mannose-4,6-dehydratase (GMDS). Loss of fucosylation led to escape of cancer cells from...
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