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Article

Evidence for GALNT12 as a moderate penetrance gene for colorectal cancer.

Human mutation - 1 Aug 2018

Evans Daniel R, Venkitachalam Srividya, Revoredo Leslie, Dohey Amanda T, Clarke Erica, Pennell Julia J, Powell Amy E, Quinn Erina, Ravi Lakshmeswari, Gerken Thomas A, Green Jane S, Woods Michael O, Guda Kishore

Abstract excerpt

Characterizing moderate penetrance susceptibility genes is an emerging frontier in colorectal cancer (CRC) research. GALNT12 is a strong candidate CRC-susceptibility gene given previous linkage and association studies, and inactivating somatic and germline alleles in CRC patients. Previously, we found rare segregating germline GALNT12 variants in a clinic-based cohort (N = 118) with predisposition for CRC. Here,...

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Source

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Identifiers

PMID: 29749045
DOI: 10.1002/humu.23549
PMCID: PMC6043371

Genes

GALNT12
MAF

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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