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Article

Proton motive force dissipation precludes interaction of microcin J25 with RNA polymerase, but enhances reactive oxygen species overproduction.

Biochimica et biophysica acta - 1 Oct 2009

Dupuy Fernando G, Chirou María V Niklison, de Arcuri Beatriz Fernández, Minahk Carlos J, Morero Roberto D

Abstract excerpt

BACKGROUND: Microcin J25 targets the RNA polymerase as well as bacterial membranes. Because there is scarce information on the relationship between the uptake and the activity, a fluorescent microcin J25-derivative was used to further characterize its mechanism of action. METHODS: MccJ25 I13K was labeled with FITC and its uptake by sensitive cells was assessed by fluorescence measurements from supernatants of...

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Identifiers

PMID: 19616604
DOI: 10.1016/j.bbagen.2009.07.006

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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