Escherichia coli RNA polymerase is the target of the cyclopeptide antibiotic microcin J25.

doi:10.1128/JB.183.15.4543-4550.2001

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Article

Escherichia coli RNA polymerase is the target of the cyclopeptide antibiotic microcin J25.

Journal of bacteriology - 1 Aug 2001

Delgado M A, Rintoul M R, Farías R N, Salomón R A

Abstract excerpt

Escherichia coli microcin J25 (MccJ25) is a plasmid-encoded, cyclic peptide antibiotic consisting of 21 unmodified amino acid residues. It is primarily active on gram-negative bacteria related to the producer strain, inducing cell filamentation in an SOS-independent way. A mutation causing resistance to MccJ25 was isolated. Genetic analysis indicated that it resided in the rpoC gene, encoding the beta' subunit of...

Topics

Alleles
Amino Acid Sequence
Anti-Bacterial Agents
Bacteriocins
Chromosome Mapping
DNA-Directed RNA Polymerases
Drug Resistance, Microbial
Escherichia coli
Genes, Bacterial
Intracellular Fluid
Leucine

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Molecular Sequence Data

Mutagenesis

Peptides

Sequence Analysis, DNA

Transcription, Genetic

Uridine

Source

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Identifiers

PMID: 11443089
DOI: 10.1128/JB.183.15.4543-4550.2001
PMCID: PMC95349

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Escherichia coli RNA polymerase is the target of the cyclopeptide antibiotic microcin J25.PMID 11443089Read ↗

Mutations of bacterial RNA polymerase leading to resistance to microcin j25.Semantic proximity Read ↗

Systematic structure-activity analysis of microcin J25.Semantic proximity Read ↗

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