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Article

Escherichia coli RNA polymerase is the target of the cyclopeptide antibiotic microcin J25.

Journal of bacteriology - 1 Aug 2001

Delgado M A, Rintoul M R, Farías R N, Salomón R A

Abstract excerpt

Escherichia coli microcin J25 (MccJ25) is a plasmid-encoded, cyclic peptide antibiotic consisting of 21 unmodified amino acid residues. It is primarily active on gram-negative bacteria related to the producer strain, inducing cell filamentation in an SOS-independent way. A mutation causing resistance to MccJ25 was isolated. Genetic analysis indicated that it resided in the rpoC gene, encoding the beta' subunit of...

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Identifiers

PMID: 11443089
DOI: 10.1128/JB.183.15.4543-4550.2001
PMCID: PMC95349

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Source receipt: pubmed, retrieved 7 Sept 2026.

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Escherichia coli RNA polymerase is the target of the cyclopeptide antibiotic microcin J25.PMID 11443089Read ↗

Mutations of bacterial RNA polymerase leading to resistance to microcin j25.Semantic proximity Read ↗

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