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Article

Genetic analysis of plasmid determinants for microcin J25 production and immunity

1 Jun 1996

Abstract excerpt

Microcin J25 (MccJ25) is a small peptide antibiotic produced by an Escherichia coli strain isolated from human feces. The genetic determinants for MccJ25 synthesis and immunity have been cloned from the low-copy-number wild-type plasmid pTUC1OO into the compatible vectors pBR322 and pACYC184. Physical and phenotypical analysis of insertion mutations and complementation tests defined three contiguous genes...

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PMID: 8655570
DOI: 10.1128/jb.178.12.3661-3663.1996

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Related research

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Genetic analysis of plasmid determinants for microcin J25 production and immunityPMID 8655570Read ↗

Microcin 25, a novel antimicrobial peptide produced by Escherichia coliSemantic proximity Read ↗

Escherichia coli RNA polymerase is the target of the cyclopeptide antibiotic microcin J25.Semantic proximity Read ↗

Escherichia coli outer membrane protein TolC is involved in production of the peptide antibiotic microcin J25.Semantic proximity Read ↗

Mutations of bacterial RNA polymerase leading to resistance to microcin j25.Semantic proximity Read ↗

Microcin J25 uptake: His5 of the MccJ25 lariat ring is involved in interaction with the inner membrane MccJ25 transporter protein SbmA.Semantic proximity Read ↗

Structure and organization of plasmid genes required to produce the translation inhibitor microcin C7.Semantic proximity Read ↗

Multispecies activity screening of microcin J25 mutants yields antimicrobials with increased specificity toward pathogenic Salmonella species relative to human commensal Escherichia coli.Semantic proximity Read ↗

Systematic structure-activity analysis of microcin J25.Semantic proximity Read ↗

Sequence diversity in the lasso peptide framework: discovery of functional microcin J25 variants with multiple amino acid substitutions.Semantic proximity Read ↗

[Mapping of plasmid genes responsible for microcin R51 synthesis and immunity to it].Semantic proximity Read ↗

Microcin J25 has dual and independent mechanisms of action in Escherichia coli: RNA polymerase inhibition and increased superoxide production.Semantic proximity Read ↗

Molecular characterization of pmbA, an Escherichia coli chromosomal gene required for the production of the antibiotic peptide MccB17.Semantic proximity Read ↗

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