Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Mutations of bacterial RNA polymerase leading to resistance to microcin j25.

The Journal of biological chemistry - 27 Dec 2002

Yuzenkova Julia, Delgado Monica, Nechaev Sergei, Savalia Dhruti, Epshtein Vitaly, Artsimovitch Irina, Mooney Rachel A, Landick Robert, Farias Ricardo N, Salomon Raul, Severinov Konstantin

Abstract excerpt

A mutation in the conserved segment of the rpoC gene, which codes for the largest RNA polymerase (RNAP) subunit, beta', was found to make Escherichia coli cells resistant to microcin J25 (MccJ25), a bactericidal 21-amino acid peptide active against Gram-negative bacteria (Delgado, M. A., Rintoul, M. R., Farias, R. N., and Salomon, R. A. (2001) J. Bacteriol. 183, 4543-4550). Here, we report that mutant RNAP...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Anti-Bacterial Agents
Share to Bacteria

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Bacteriocins

Share to DNA-Directed RNA Polymerases

Share to Drug Resistance, Bacterial

Share to Gram-Negative Bacteria

Share to Peptides

Share to Protein Subunits

Source

Identifiers

PMID: 12401787
DOI: 10.1074/jbc.M209425200

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Mutations of bacterial RNA polymerase leading to resistance to microcin j25.PMID 12401787Read ↗

Escherichia coli RNA polymerase is the target of the cyclopeptide antibiotic microcin J25.Semantic proximity Read ↗

Systematic structure-activity analysis of microcin J25.Semantic proximity Read ↗

Sequence diversity in the lasso peptide framework: discovery of functional microcin J25 variants with multiple amino acid substitutions.Semantic proximity Read ↗

Microcin J25 uptake: His5 of the MccJ25 lariat ring is involved in interaction with the inner membrane MccJ25 transporter protein SbmA.Semantic proximity Read ↗

Genetic analysis of plasmid determinants for microcin J25 production and immunitySemantic proximity Read ↗

Microcin J25 has dual and independent mechanisms of action in Escherichia coli: RNA polymerase inhibition and increased superoxide production.Semantic proximity Read ↗

Construction and characterization of mutations at codon 751 of the Escherichia coli gyrB gene that confer resistance to the antimicrobial peptide microcin B17 and alter the activity of DNA gyrase.Semantic proximity Read ↗

Proton motive force dissipation precludes interaction of microcin J25 with RNA polymerase, but enhances reactive oxygen species overproduction.Semantic proximity Read ↗

Escherichia coli outer membrane protein TolC is involved in production of the peptide antibiotic microcin J25.Semantic proximity Read ↗

Phenomic and genomic approaches to studying the inhibition of multiresistant Salmonella enterica by microcin J25Semantic proximity Read ↗

Multispecies activity screening of microcin J25 mutants yields antimicrobials with increased specificity toward pathogenic Salmonella species relative to human commensal Escherichia coli.Semantic proximity Read ↗

The peptide antibiotic microcin B17 induces double-strand cleavage of DNA mediated by E. coli DNA gyrase.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.