Article
Microcin J25 uptake: His5 of the MccJ25 lariat ring is involved in interaction with the inner membrane MccJ25 transporter protein SbmA.
Journal of bacteriology - 1 May 2006
de Cristóbal Ricardo E, Solbiati Jose O, Zenoff Ana M, Vincent Paula A, Salomón Raul A, Yuzenkova Julia, Severinov Konstantin, Farías Ricardo N
Abstract excerpt
Escherichia coli microcin J25 (MccJ25) is a plasmid-encoded antibiotic peptide consisting of 21 L-amino acid residues (G1-G-A-G-H5-V-P-E-Y-F10-V-G-I-G-T15-P-I-S-F-Y20-G). E. coli RNA polymerase (RNAP) is the intracellular target of MccJ25. MccJ25 enters cells after binding to specific membrane transporters: FhuA in the outer membrane and SbmA in the inner membrane. Here, we studied MccJ25 mutants carrying a...
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