Article
Expression and In Vivo Characterization of the Antimicrobial Peptide Oncocin and Variants Binding to Ribosomes.
Biochemistry - 15 Sept 2020
Muthunayake Nisansala S, Islam Rabiul, Inutan Ellen D, Colangelo Wesley, Trimpin Sarah, Cunningham Philip R, Chow Christine S
Abstract excerpt
Peptides have important biomedical applications, but poor correlation between in vitro and in vivo activities can limit their development for clinical use. The ability to generate peptides and monitor their expression with new mass spectrometric methods and biological activities in vivo would be an advantage for the discovery and improvement of peptide-based drugs. In this study, a plasmid-based system was used...
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