Article
CTLA4 autoimmunity-associated genotype contributes to severe pulmonary tuberculosis in an African population.
PloS one - 17 Jul 2009
Thye Thorsten, Scarisbrick Genevieve, Browne Edmund N L, Chinbuah Margaret Amanua, Gyapong John, Osei Ivy, Owusu-Dabo Ellis, Niemann Stefan, Rüsch-Gerdes Sabine, Meyer Christian G, Horstmann Rolf D
Abstract excerpt
The gene of Cytotoxic T Lymphocyte-associated Antigen 4 (CTLA4), a negative regulator of T lymphocytes, contains a single-nucleotide polymorphism (SNP) at position +6230A->G (ct60A->G), which has been found associated with several autoimmune diseases and appears to reduce T-cell inhibitory activi...
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