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Article

Association of CTLA4 gene polymorphisms with susceptibility and pathology correlation to pulmonary tuberculosis in Southern Han Chinese.

International journal of biological sciences - 1 Jan 2012

Wang Chong, Jiang Tingting, Wei Liliang, Li Fujian, Sun Xiaojun, Fan Dapeng, Liu Jiyan, Zhang Xing, Xu Dandan, Chen Zhongliang, Li Zhongjie, Fu Xiaoyan, Li Ji-Cheng

Abstract excerpt

The cytotoxic T lymphocyte antigen-4 (CTLA4) gene is a key negative regulator of the T lymphocyte immune response. It has been found that CTLA4 +49A>G (rs231775), +6230G>A (rs3087243), and 11430G>A (rs11571319) polymorphisms are associated with susceptibility to many autoimmune diseases, and can down-regulate the inhibition of cellular immune response of CTLA4. Three SNPs in CTLA4 were genotyped by using the PCR...

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Share to Adolescent
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Share to Genetic Predisposition to Disease
Share to Polymorphism, Single Nucleotide
Share to Tuberculosis, Pulmonary
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Source

Open in PubMed Open full text

Identifiers

PMID: 22811616
DOI: 10.7150/ijbs.4390
PMCID: PMC3399317

Genes

CTLA4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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