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Article

Pathophysiology of thalassaemia.

Bailliere's clinical haematology - 1 Mar 1998

Weatherall D J

Abstract excerpt

Most of the major clinical manifestations of the beta-thalassaemias can be related to the deleterious effects of imbalanced globin chain synthesis on erythroid maturation and red cell survival. The destruction of red cell progenitors and their progeny results from an extremely complex series of mechanisms all related to the presence of excess alpha-globin chain production. These include mechanical damage,...

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Identifiers

PMID: 10872475
DOI: 10.1016/s0950-3536(98)80072-3

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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