Pathophysiology of thalassemia

Abstract excerpt

Despite discoveries concerning the molecular abnormalities that led to the thalassemic syndromes, it still is not known how accumulation of excess unmatched alpha-globin in beta thalassemia and beta-globin in alpha thalassemia leads to red blood cell hemolysis in the peripheral blood, and in the beta thalassemias particularly, premature destruction of erythroid precursors in marrow (ineffective erythropoiesis)....

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Erythrocyte Function and Pathophysiology
• Share to Hemoglobinopathies and Related Disorders
• Share to Neonatal Health and Biochemistry