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Article

Restoration of the balanced alpha/beta-globin gene expression in beta654-thalassemia mice using combined RNAi and antisense RNA approach.

Human molecular genetics - 1 Nov 2007

Xie Shu-Yang, Ren Zhao-Rui, Zhang Jing-Zhi, Guo Xin-Bin, Wang Qing-Xue, Wang Shu, Lin Dan, Gong Xiu-Li, Li Wei, Huang Shu-Zhen, Zeng Fanyi, Zeng Yi-Tao

Abstract excerpt

The beta-thalassemia is associated with abnormality in beta-globin gene, leading to imbalanced synthesis of alpha-/beta-globin chains. Consequently, the excessive free alpha-globin chains precipitate to the erythrocyte membrane, resulting in hemolytic anemia. We have explored post-transcriptional strategies aiming at alpha-globin reduction and beta-globin enrichment on beta(654) (Hbb(th-4)/Hbb(+)) mouse, carrying...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 17716993
DOI: 10.1093/hmg/ddm218

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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