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Ganglioside GT1b Is a Putative Host Cell Receptor for the Merkel Cell Polyomavirus

16 Jul 2009

Abstract excerpt

The Merkel cell polyomavirus (MCPyV) was identified recently in human Merkel cell carcinomas, an aggressive neuroendocrine skin cancer. Here, we identify a putative host cell receptor for MCPyV. We found that recombinant MCPyV VP1 pentameric capsomeres both hemagglutinated sheep red blood cells and interacted with ganglioside GT1b in a sucrose gradient flotation assay. Structural differences between the analyzed...

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PMID: 19605473
DOI: 10.1128/jvi.00949-09

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